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Aug. 12, 1941. E. w. WEBB PROCESS FOR MAKING AND ASSEMBLING SIDE BEARINGS Filed July 5, 1940 Carbostyril derivative or a pharmaceutically acceptable acid addition salt thereof, having excellent platelate aggregation inhibitory effect, calcium antagonism, hypotensive effect and phosphodiesterase inhibitory effect are useful as prophylactic or treating agents for throm- 8 bosis, circulation improving agents for coronary blood flow such as coronary vasodilators, hypotensive agents and phosphodiesterase inhibitors. Furthermore, the carbostyril derivatives are weak in heart rate increasing activity and also in cardiac muscle contraction increasing activity, and the carbostyril derivatives are useful Carbostyril derivative or a pharmaceutically acceptable acid addition salt thereof, having excellent platelate aggregation inhibitory effect, calcium antagonism, hy-

potensive effect and phosphodiesterase inhibitory effect are useful as prophylactic or treating agents for thrombosis, circulation improving agents for coronary blood flow such as coronary vasodilators, hypotensive agents and phosphodiesterase inhibitors. Furthermore, the

carbostyril derivatives are weak in heart rate increasing activity and also in cardiac muscle contraction increasx 882T u o c x 0323+ u o 2 ob ing act1v1ty, and the carbostyril derivatives are useful fire/m) K r 5 carbostyril derivative or a phan'naoeutically acce table acid addition salt thereof. having excellent plalelatc aggregation inhibitory etlect, calcium antagonism, hy otensivc effect and phosphodiesteme inhibitory effect 4 PT are useful as ro hylactic or treating agcnls for thrombosis, circulation improving a ents for coronary blood flow such as coronary vasodilators, hy otensive agcnls and phosphodiesierase inhibitors. Furthermore, the carbostyril derivatives are wuk in heart rate increasing activity and also in cardiac muscle contraction increasing activity, and the carbostyril derivatives are useful 1 zy+K3z+ "i +K- 12 x R227 u 0 :L: L: x 823+ u o 2 x 5257 u 0 L: x :52? v 0 0 0 u o 0 0 H o 0 0 u m 3 n o. Av C E ATS f Mmmm mmm v mmm m E n N 255 m t 01234 mo ilittl h rltriilrr 1:1 rlnitalltlrrhllrrsu Iii inlet) I a :.:)a)\- lll lll 2 IMAGE SYSTEM TEST TARGET u.s. DEPARTMENT OF COMMERCE PATENT AND TRADEMARK OFFICE ZIIIIIII/l/II ill . I ll/1111104177 Ni i 101.2 Aperture ratio: lagnification of projection: [alf angle of view:

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